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Mode of Action
Wound Healing Properties
Preclinical Developments

All the following results were obtained in collaboration with Biomatech in Chasse sur Rhône – France, according to ISO 10993 standards under GMP conditions.

Official toxicity and biocompatibility tests were carried out with the Globin paste:

  • Intracutaneous irritation test by intradermal injection in the rabbit;
  • Acute systemic toxicity study in the mouse;
  • Sensitization study in the guinea pig (with guinea pig Globin);
  • Mouse bone marrow micronucleus study;
  • In vitro cytotoxicity study;
  • Evaluation of the mutagenicity: Ames test;
  • Evaluation of chromosomal aberrations induction in human cells;
  • Evaluation of the local tolerance following intradermal injection in the nude rat;
  • 13 week subchronic toxicity study in rats following a subcutaneous injection of human Globin;
  • Local effects and performance of a rat globin in a subcutaneous injection model in the rat;
  • Local effects and performance of a porcine globin in a subcutaneous injection model in the pig.

Bactericidal and fungicidal properties of the globin paste were demonstrated in collaboration with Mycoscience – Willington CT – USA, against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans.

All the corresponding reports show satisfactory results.